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Microbiota-derived butyrate dampens linaclotide stimulation of the guanylate cyclase C pathway in patient-derived colonoids.
Modulation of matrix remodeling by SPARC in neoplastic progression.
CORRIGENDUM: The Evidence of Glioblastoma Heterogeneity.
Multiorganizational consensus to define guiding principles for perioperative pain management in patients with chronic pain, preoperative opioid tolerance, or substance use disorder.
Genome-wide association study of milk and reproductive traits in dual-purpose Xinjiang Brown cattle.
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Froelich, Christopher
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Froelich, Christopher
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Concept
DNA Fragmentation
Academic Article
BCL-2 blocks perforin-induced nuclear translocation of granzymes concomitant with protection against the nuclear events of apoptosis.
Academic Article
Purification and use of granzyme B.
Academic Article
Perforin-dependent nuclear entry of granzyme B precedes apoptosis, and is not a consequence of nuclear membrane dysfunction.
Academic Article
Reconstitution of caspase 3 sensitizes MCF-7 breast cancer cells to doxorubicin- and etoposide-induced apoptosis.
Academic Article
Granzyme B activates procaspase-3 which signals a mitochondrial amplification loop for maximal apoptosis.
Academic Article
Granzyme-mediated cytotoxicity does not involve the mannose 6-phosphate receptors on target cells.
Academic Article
Human granzyme B is essential for DNA fragmentation of susceptible target cells.
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DNA Fragmentation